Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vascular RAA system

J D Swales1, N J Samani

  • 1Department of Medicine, Leicester Royal Infirmary, UK.

Journal of Human Hypertension
|August 1, 1993
PubMed
Summary
This summary is machine-generated.

The extrarenal renin-angiotensin-aldosterone (RAA) system exists in tissues, contributing to hypertension. Local renin synthesis and activity in organs like the aorta play a role in blood pressure regulation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Measurement and initial characterization of leukocyte telomere length in 474,074 participants in UK Biobank.

Nature aging·2023
Same author

SVEP1 influences monocyte to macrophage differentiation via integrin α4β1/α9β1 and Rho/Rac signalling.

Biochimica et biophysica acta. Molecular cell research·2023
Same author

Alcohol consumption and telomere length: Mendelian randomization clarifies alcohol's effects.

Molecular psychiatry·2022
Same author

Tumour biomarkers: association with heart failure outcomes.

Journal of internal medicine·2020
Same author

Novel endotypes in heart failure: effects on guideline-directed medical therapy.

European heart journal·2018
Same author

Response to the letter by Esteves et al.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2018
Same journal

Patient out-of-pocket costs for antihypertensive single pill combination products with cost caps.

Journal of human hypertension·2026
Same journal

Mindfulness based interventions for blood pressure reduction: systematic and umbrella review of existing meta-analyses.

Journal of human hypertension·2026
Same journal

Invasive observation of reactive systolic blood pressure responses to upper-arm cuff inflation.

Journal of human hypertension·2026
Same journal

Association between post-thrombectomy blood pressure trajectories and clinical outcomes in hypertensive patients with acute ischemic stroke: a retrospective cohort study.

Journal of human hypertension·2026
Same journal

Systemic inflammation indices generated from first-trimester blood tests can be potential biomarkers for predicting preeclampsia.

Journal of human hypertension·2026
Same journal

Chronotherapy in hypertension: a systematic review and meta-analysis of antihypertensive dosing timing on cardiovascular outcomes.

Journal of human hypertension·2026
See all related articles

Area of Science:

  • Physiology
  • Cardiovascular Research
  • Endocrinology

Background:

  • The function of tissue renin-angiotensin-aldosterone (RAA) systems remains incompletely understood despite evidence of their existence.
  • Renin, crucial for blood pressure regulation, can be sourced from plasma uptake or local synthesis within tissues.

Purpose of the Study:

  • To investigate the role and function of extrarenal renin-angiotensin-aldosterone (RAA) systems in cardiovascular regulation and hypertension.
  • To explore the contribution of local renin synthesis and activity in various organs to blood pressure homeostasis.

Main Methods:

  • Utilizing biochemical and bioassay techniques to detect and quantify renin activity in tissue.
  • Analyzing renin gene expression in organs such as the liver, brain, and arterial wall.

Related Experiment Videos

  • Investigating the effects of renin gene manipulation in genetic models and cross-species studies.

    • Main Results:

    • Evidence confirms renin presence and retention in arterial tissue, notably the aortic wall, correlating with elevated blood pressure.
    • Renin gene expression is detected in multiple organs, suggesting localized functions.
    • Intracellular angiotensin II receptors are identified, implicating them in gene expression regulation.
    • Studies involving renin gene constructs in rats demonstrated severe hypertension, even with suppressed renal renin.

    Conclusions:

    • The extrarenal renin-angiotensin-aldosterone (RAA) system plays a significant pathogenetic role in certain forms of hypertension.
    • Local renin synthesis and activity in non-renal tissues are critical factors in blood pressure regulation and disease development.