Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genetic factors in multiple sclerosis

J R Oksenberg1, A B Begovich, H A Erlich

  • 1Department of Neurology and Neurological Sciences, Stanford University School of Medicine, CA 94143-0114.

JAMA
|November 17, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The genetic diversity of multiple sclerosis risk among Hispanic and African American populations living in the United States.

Multiple sclerosis (Houndmills, Basingstoke, England)·2019
Same author

The killer immunoglobulin-like receptor KIR3DL1 in combination with HLA-Bw4 is protective against multiple sclerosis in African Americans.

Genes and immunity·2016
Same author

Very high resolution single pass HLA genotyping using amplicon sequencing on the 454 next generation DNA sequencers: Comparison with Sanger sequencing.

Human immunology·2015
Same author

Genetic associations with brain cortical thickness in multiple sclerosis.

Genes, brain, and behavior·2015
Same author

Next-generation sequencing can reveal in vitro-generated PCR crossover products: some artifactual sequences correspond to HLA alleles in the IMGT/HLA database.

Tissue antigens·2013
Same author

Genetic burden in multiple sclerosis families.

Genes and immunity·2013

Investigating genetic factors in multiple sclerosis (MS) reveals weak associations for major histocompatibility complex (MHC) and T-cell receptor (TCR) genes. TCR gene analysis in the MS brain identified a key immune target, aiding understanding of autoimmune demyelination.

Area of Science:

  • Neuroimmunology
  • Genetics
  • Autoimmunity

Background:

  • Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system.
  • The genetic underpinnings of MS susceptibility are complex and not fully understood.
  • Candidate gene studies have explored various genetic loci, including the major histocompatibility complex (MHC) and T-cell receptor (TCR) genes.

Purpose of the Study:

  • To evaluate the contribution of candidate genes to multiple sclerosis (MS) susceptibility.
  • To elucidate the role of T-cell receptor (TCR) gene rearrangements within MS brain lesions.
  • To identify a primary target of the immune response in MS pathogenesis.

Main Methods:

  • Comprehensive review of published literature and unpublished studies.

Related Experiment Videos

  • Analysis of molecular approaches investigating MHC and TCR gene complexes in MS.
  • Examination of epigenetic events related to TCR genes and review of immunotherapy trials.

    • Main Results:

    • Associations between MHC and TCR genes with MS susceptibility are generally weak, supporting a polygenic model.
    • No other candidate genes have been definitively established as major contributors to MS risk.
    • Analysis of TCR gene rearrangements in brain lesions successfully identified a significant target of the immune system in MS.

    Conclusions:

    • Understanding the genetic basis of autoimmune demyelination is crucial for advancing MS treatment.
    • Identifying specific immune targets offers potential for novel therapeutic strategies in MS.