Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Altered platelet function in diabetes mellitus

J A Colwell, P V Halushka, K Sarji

    Diabetes
    |January 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Is aspirin effective in diabetic patients? Yes.

    Journal of thrombosis and haemostasis : JTH·2005
    Same author

    Inositol treatment has no effect on the dexamethasone suppression test.

    The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry·2003
    Same author

    The evolving role of topiramate among other mood stabilizers in the management of bipolar disorder.

    Bipolar disorders·2002
    Same author

    Softform for facial rejuvenation: historical review, operative techniques, and recent advances.

    Facial plastic surgery : FPS·2002
    Same author

    Comparison of open and endoscopic treatment of posttraumatic posterior urethral strictures.

    World journal of surgery·2002
    Same author

    Treatment for the procoagulant state in type 2 diabetes.

    Endocrinology and metabolism clinics of North America·2001
    Same journal

    Females Are Completely Resistant to Semaglutide-Induced Muscle Loss in ob/ob Mice.

    Diabetes·2026
    Same journal

    Ketone Bodies Derived From Medium-Chain Triglycerides Support Brain Metabolism and Function Under Hypoglycemia in Type 1 Diabetes Mellitus.

    Diabetes·2026
    Same journal

    Targeting the ADA/ADO Axis Rescues β-Cell Failure in Type 2 Diabetes.

    Diabetes·2026
    Same journal

    TXNIP Is Positioned as a Key Mediator of Hyperglycemia-Induced Vascular Senescence.

    Diabetes·2026
    Same journal

    Sex Differences in ER Stress Pathways Are a Key Determinant of β-Cell Proliferation and Resilience.

    Diabetes·2026
    Same journal

    The Mechanism of TNF-α Combined With High Glucose in Regulating Calnexin Aggravates Endoplasmic Reticulum Stress in Endothelial Cell Injury of Diabetic Retinopathy.

    Diabetes·2026
    See all related articles

    Diabetic platelets show increased aggregation due to elevated von Willebrand factor (vWF) and prostaglandin activity. Aspirin can reverse this, suggesting therapeutic targets for preventing diabetic vascular disease.

    Area of Science:

    • Biochemistry
    • Hematology
    • Endocrinology

    Background:

    • Platelets in diabetic individuals exhibit heightened sensitivity to aggregation triggers like ADP and epinephrine.
    • This increased platelet sensitivity is linked to elevated levels of von Willebrand factor (vWF), potentially influenced by growth hormone.

    Purpose of the Study:

    • To investigate the mechanisms behind increased platelet aggregation in diabetes mellitus.
    • To explore the role of von Willebrand factor and prostaglandin synthesis in diabetic platelet function.

    Main Methods:

    • Assessed platelet aggregation in response to ADP, epinephrine, and arachidonic acid in diabetic and normal subjects.
    • Measured von Willebrand factor (vWF) activity and prostaglandin E2-like material (iPGE) synthesis in platelets.

    Related Experiment Videos

  • Evaluated the effect of aspirin, a prostaglandin synthetase inhibitor, on platelet aggregation.

    • Main Results:

    • Diabetic platelets demonstrated increased aggregation sensitivity to ADP, epinephrine, and arachidonic acid compared to normal platelets.
    • Elevated vWF levels correlated with increased platelet aggregation sensitivity.
    • Platelets from diabetics synthesized more PGE2-like material (iPGE) in response to various stimuli, indicating enhanced prostaglandin synthetase activity.
    • Aspirin abolished the heightened sensitivity of diabetic platelets to arachidonic acid-induced aggregation.

    Conclusions:

    • Increased prostaglandin synthetase activity is a key mechanism driving platelet hyperaggregability in diabetes.
    • Elevated vWF levels contribute to platelet sensitivity in diabetic patients.
    • Therapeutic strategies targeting growth hormone, vWF activity, or prostaglandin synthetase may help prevent vascular complications in diabetes.