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Role of magnesium in the management of hypertension

M Shafique1, Misbah-ul-Ain, M Ashraf

  • 1Department of Biochemistry, Quaid-i-Azam Medical College, Islamia University, Bahawalpur.

JPMA. the Journal of the Pakistan Medical Association
|April 1, 1993
PubMed

Insights

Magnesium chloride supplementation effectively lowered blood pressure in patients with arterial hypertension and congestive heart failure. This study found significant reductions in both systolic and diastolic pressures without adverse electrolyte changes.

Area of Science:

  • Cardiology
  • Nephrology
  • Clinical Nutrition

Background:

  • Diuretic therapy is common for arterial hypertension and congestive heart failure.
  • Long-term diuretic use can affect electrolyte balance.
  • Magnesium plays a role in cardiovascular health.

Purpose of the Study:

  • To investigate the effect of magnesium chloride supplementation on blood pressure in patients on diuretic treatment.
  • To assess changes in serum and urinary electrolytes during magnesium supplementation.

Main Methods:

  • A study involving 22 patients with arterial hypertension or congestive heart failure on long-term diuretic treatment.
  • Patients received 10 mmol/day of magnesium chloride for four months.
  • Blood pressure, serum, and urinary electrolytes were monitored.

Main Results:

  • Significant reductions in both systolic and diastolic blood pressure were observed (mean decrease of 13 +/- 9 mmHg).
  • No significant changes in serum or urinary electrolytes were noted, apart from magnesium levels.
  • Magnesium supplementation was well-tolerated.

Conclusions:

  • Magnesium chloride supplementation can be an effective adjunctive therapy for lowering blood pressure in patients with arterial hypertension and congestive heart failure.
  • This intervention appears safe regarding electrolyte balance, with the exception of increased magnesium levels.
  • Further research may explore optimal magnesium dosages and long-term cardiovascular benefits.

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