Detection of coronary artery stenosis by dipyridamole radionuclide ventriculography

We assessed the usefulness of dipyridamole radionuclide ventriculography for detecting significant coronary artery stenosis in 89 patients who were undergoing cardiac catheterization. Radionuclide ventriculography was performed before and after the infusion of dipyridamole (0.56 mg/kg). The end-diastolic regions of interest of the left ventricle were divided into 5 sectors for calculation of the regional ejection fractions. Results were considered to be positive when the regional ejection fraction decreased by more than 5% after the infusion of dipyridamole. The presence of significant coronary artery stenosis (> 75%) was demonstrated by arteriography in 49 patients and was absent in 40 patients. A decrease in the regional ejection fraction greater than 5% was observed in 41 (84%) of the 49 patients with significant coronary artery stenosis and in 2 of the 40 without significant coronary stenosis. The sensitivity and specificity of this method for detecting significant coronary artery stenosis were 84% and 95%, respectively. We conclude that a decrease in the radionuclide-determined regional ejection fraction after the infusion of dipyridamole reflects left ventricular dysfunction and is a sensitive and specific indicator of significant coronary artery stenosis.