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A ureteral small cell carcinoma mixed with malignant mesodermal and ectodermal elements: a clinicopathological,
M Tsutsumi1, M Kamiya, M Sakamoto
1Urology Division, National Cancer Center Hospital, Tokyo.
Japanese Journal of Clinical Oncology
|October 1, 1993
Summary
This case report details a rare small cell carcinoma of the ureter with diverse histological components. The patient received treatment for both the primary ureteral tumor and a subsequent bladder neck tumor.
Area of Science:
- Uro-oncology
- Rare tumors
- Histopathology
Background:
- Small cell carcinoma (SCC) is an aggressive neuroendocrine tumor rarely found in the urinary tract.
- Ureteral SCC is exceptionally rare, with limited documented cases.
Observation:
- A 60-year-old male presented with a primary small cell carcinoma of the right lower ureter.
- The tumor exhibited diverse histological types, including transitional cell carcinoma, squamous cell carcinoma, adenocarcinoma, leiomyosarcoma, and chondrosarcoma.
- Immunohistochemical staining confirmed SCC and chondrosarcoma components.
Findings:
- The patient underwent nephroureterectomy, pelvic/para-aortic lymph node radiation, and cisplatin/etoposide chemotherapy.
- Eight months post-chemotherapy, a transitional cell carcinoma developed at the bladder neck, necessitating cystectomy and urethrectomy.
- This represents the second reported case of ureteral small cell carcinoma.
Implications:
- Highlights the aggressive nature and potential for diverse histology in rare ureteral tumors.
- Underscores the importance of comprehensive histopathological evaluation and surveillance for secondary malignancies.
- Contributes to the limited literature on ureteral small cell carcinoma, aiding future clinical management and research.