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[Coronary artery bypass grafting in six patients with familial hypercholesterolemia]
T Hiranaka1, N Sakagoshi, Y Furutani
1Department of Cardiovascular Surgery, Kinan General Hospital, Wakayama, Japan.
Insights
Coronary artery bypass grafting (CABG) is effective for familial hypercholesterolemia (FH) patients, showing a 100% graft patency rate and no early deaths. Surgical interventions in FH patients yielded positive short-term outcomes.
Area of Science:
- Cardiovascular Surgery
- Medical Genetics
- Vascular Surgery
Background:
- Familial hypercholesterolemia (FH) is a genetic disorder leading to high cholesterol and premature cardiovascular disease.
- Surgical interventions are considered for FH patients with severe coronary artery disease.
- Coronary artery bypass grafting (CABG) is a common surgical procedure for managing coronary artery disease.
Observation:
- Six patients with familial hypercholesterolemia underwent surgical treatment between June 1989 and November 1991.
- Procedures included isolated CABG, CABG with coronary aneurysm ligation, and CABG with femoro-femoral bypass.
- A specific case involved a 44-year-old man with recurrent angina 11 years post-CABG, who underwent successful aneurysm ligation and internal mammary artery grafting.
Findings:
- There were no operative or hospital deaths among the six patients.
- The early postoperative graft patency rate was 100%.
- The patient undergoing aneurysm ligation remained asymptomatic postoperatively, indicating successful management.
Implications:
- CABG demonstrates effectiveness in the early postoperative period for patients with familial hypercholesterolemia.
- Surgical management, including complex procedures like aneurysm ligation, can be beneficial for FH patients.
- These findings support the role of surgical intervention in managing advanced coronary artery disease in FH.
Unlabelled:
From June 1989 through November 1991, six patients with familial hypercholesterolemia underwent surgical treatments. The surgical procedures were coronary artery bypass grafting (CABG) alone 4, ligation of coronary aneurysm + CABG 1, and CABG + femoro-femoral bypass 1. There were no operative or hospital deaths. Early post operative patency rate of the grafts was 100%.
Case Presentation:
A 44-year-old man whose anginal pain recurred 11 years after CABG. Coronary angiogram revealed stenosis and a large aneurysm in the circumflex coronary artery. Previous grafts to the left anterior descending coronary artery and diagonal branch were patent. Ligation of the aneurysm and internal mammary artery bypass grafting were performed. Postoperatively, the patient has remained asymptomatic. Our data indicate that CABG for FH patients is effective in the early postoperative period.