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[Magnesium protects myocardium during electric cardioversion but does not increase effectiveness]
A Szyszka1, H Wachowiak-Baszyńska, J Kaczmarek
1Instytutu Kardiologii Akademii Medycznej, Poznaniu.
Kardiologia Polska
|February 1, 1993
Summary
Magnesium sulfate pretreatment before electrical cardioversion (EC) significantly reduces cardiac enzyme elevation and repolarization abnormalities. This cardioprotective effect aids recovery in patients with chronic atrial fibrillation post-valve surgery.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Electrical cardioversion (EC) for chronic atrial fibrillation can cause transient serum enzyme elevation and repolarization abnormalities.
- These effects are common in patients undergoing EC after valve surgery.
Purpose of the Study:
- To investigate the cardioprotective effects of magnesium sulfate (MgSO4) pretreatment in mitigating EC-induced alterations.
- To assess the impact of MgSO4 on serum enzyme levels and repolarization abnormalities.
Main Methods:
- A randomized study involving 100 patients (aged 19-65) with chronic atrial fibrillation post-valve surgery undergoing EC.
- Patients were divided into two groups: 50 received intravenous MgSO4 (100 mg/kg b.w.) and 50 served as controls.
- Serum magnesium and CKMB levels, recovery to sinus rhythm, QTc interval, and segment shifts were monitored before and after EC.
Main Results:
- MgSO4 pretreatment demonstrated a significant reduction in CKMB levels and repolarization abnormalities post-EC.
- Patients receiving MgSO4 showed improved recovery to sinus rhythm and normalized QTc intervals compared to controls.
Conclusions:
- Intravenous magnesium sulfate administration prior to electrical cardioversion offers a significant cardioprotective effect.
- MgSO4 effectively reduces post-EC serum enzyme elevations and mitigates adverse repolarization abnormalities.