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[Immunity coverage against measles, rubella and parotiditis viruses in a juvenile population in Leon, Spain]
J Suárez1, M R Castañeda, C B Gutiérrez
1Departamento de Patología Animal (Sanidad Animal), Universidad de León.
Insights
Vaccination significantly boosts immunity against measles, rubella, and parotiditis in children. However, susceptibility remains high for these diseases, highlighting the need for continued vaccination efforts.
Area of Science:
- Pediatrics
- Immunology
- Public Health
Context:
- Assesses immunity coverage and seroprevalence of IgG antibodies against measles, rubella, and parotiditis viruses.
- Focuses on a juvenile population of 50,398 children in the Leon healthcare area.
- Investigates the impact of vaccination status and prior disease history on antibody presence.
Purpose:
- To evaluate the seroprevalence of IgG antibodies against measles, rubella, and parotiditis in children aged 5-14.
- To determine the effectiveness of vaccination and previous infection in conferring immunity.
- To identify remaining population susceptibility to these viral infections.
Summary:
- 60% of children had antibodies against all three viruses, 27% against two, and 9% against one; 3% had no antibodies.
- Seroprotection rates were highest for measles (87%), followed by rubella (80%) and parotiditis (77%).
- Children with a history of measles or parotiditis showed higher antibody levels than vaccinated children, unlike rubella.
Impact:
- Vaccination is the primary determinant of immunity in the studied juvenile population.
- Significant percentages of children remain susceptible: measles (13%), rubella (20%), and parotiditis (23%).
- Findings underscore the ongoing importance of vaccination programs to maintain population immunity and prevent outbreaks.
Background:
The immunity coverage, seroprevalence of IgG antibodies against infection by measles, rubella and parotiditis viruses in a juvenile population (50,398 children) was studied.
Methods:
Systematic sampling was performed among children from 5-14 years of age who had undergone clinical analysis in the health care area of Leon. The hypothesis of sampling was the most unfavorable (p = q = 0.5) and the size of the sample of 600 children. Information was collected on vaccination state, previous history of disease and place of residence. The presence/absence of IgG antibodies was investigated by a commercial immunoenzymatic technique (EIA-Stat Measles, Mumps, Rubella, Whittaker Bioproducts, USA).
Results:
Sixty percent of the children studied had IgG antibodies against the three virus, 27% against two and 9% against only one with absence of antibodies against the three virus in 3%. The seroprotection observed was significantly higher (p < 0.05) for measles (87% +/- 3%) that for the other two diseases (rubella 80% +/- 3% and parotiditis 77% +/- 3%). In the group of children with previous history of measles and parotiditis a higher percentage of antibodies (p < 0.01) was observed than in the group with previous history of vaccination (measles: 94% versus 84%, parotiditis: 90% versus 75%). No difference was observed in the case of rubella.
Conclusions:
Vaccination is still the principal conditioning factor of the state of immunity of the juvenile population in Leon in relation with the diseases studied (measles, rubella, parotiditis). The place of residence (rural or urban) did not condition different immunity coverage in the sample studied. The susceptibility of infection for some of these virus continues to be high: measles 13%, rubella 20% and parotiditis 23%).