Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dynamic imaging with T2* contrast using U-FLARE

D G Norris1, M Hoehn-Berlage, F Wittlich

  • 1Fachbereich Chemie, Universität Bremen, Germany.

Magnetic Resonance Imaging
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Editorial of the Special Issue: Parallel Problem Solving from Nature PPSN 2024 Extended Versions of Best Paper Candidates.

Evolutionary computation·2026
Same author

Isospin Properties of Nuclear Pair Correlations from the Level Structure of the Self-Conjugate Nucleus ^{88}Ru.

Physical review letters·2020
Same author

White matter changes and gait decline in cerebral small vessel disease.

NeuroImage. Clinical·2017
Same author

Reduced functional connectivity within the primary motor cortex of patients with brachial plexus injury.

NeuroImage. Clinical·2016
Same author

Baseline white matter microstructural integrity is not related to cognitive decline after 5 years: The RUN DMC study.

BBA clinical·2015
Same author

Diffusion tensor imaging of the hippocampus predicts the risk of dementia; the RUN DMC study.

Human brain mapping·2015
Same journal

Systematic comparison of MPRAGE and BRAVO T1-weighted MRI pulse sequences and brain morphometry in high-risk young adults.

Magnetic resonance imaging·2026
Same journal

Foot dynamic contrast-enhanced MRI for assessing microcirculatory changes after endovascular therapy in peripheral artery disease: A prospective pilot study.

Magnetic resonance imaging·2026
Same journal

Reconstruction of MRI from undersampled k-spaces of double-contrast volume acquisitions using deep neural networks.

Magnetic resonance imaging·2026
Same journal

Radiofrequency-induced heating safety of brain MRI scans at 7 T in the presence of a shoulder implant.

Magnetic resonance imaging·2026
Same journal

Incremental diagnostic value of microstructural time-dependent diffusion MRI in differentiating PCNSL from glioblastoma over conventional MRI.

Magnetic resonance imaging·2026
Same journal

Enhanced respiratory motion compensation in free-breathing dynamic contrast-enhanced MRI with GROG-facilitated bunch phase encoding and Golden angle radial sampling.

Magnetic resonance imaging·2026
See all related articles

Dynamic T2* changes in the rat brain were monitored using the U-FLARE sequence. This method is viable for dynamic T2* measurement, applicable to perfusion and functional brain imaging.

Area of Science:

  • Neuroimaging
  • Magnetic Resonance Imaging
  • Physiology

Background:

  • Dynamic susceptibility contrast (DSC) MRI is crucial for assessing cerebral blood flow.
  • T2* changes reflect blood flow and oxygenation, but rapid dynamic monitoring remains challenging.
  • Gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA) is a common contrast agent for MRI.

Purpose of the Study:

  • To evaluate the Uridine-FLARE (U-FLARE) sequence for dynamic T2* monitoring in the rat brain.
  • To assess the feasibility of U-FLARE for imaging perfusion and functional brain activation.
  • To investigate the impact of varying blood carbon dioxide levels on T2* signals.

Main Methods:

  • Rats were injected with Gd-DTPA contrast agent.
  • Dynamic T2* changes were monitored using the U-FLARE MRI sequence.

Related Experiment Videos

  • Image acquisition achieved a temporal resolution of 1 second with adequate spatial resolution and contrast.
  • Intensity-time curves and parametric maps of regional cerebral blood flow (rCBV) were generated.
  • Experiments were conducted at three different blood pCO2 levels.

    • Main Results:

    • The U-FLARE sequence demonstrated sensitivity to dynamic T2* changes.
    • Adequate spatial resolution and contrast were achieved with a 1-second temporal resolution.
    • Intensity-time curves and rCBV parametric images were successfully generated.
    • The method showed clear dynamic T2* changes in response to Gd-DTPA injection.

    Conclusions:

    • The U-FLARE sequence is a viable method for dynamically measuring T2* changes in the brain.
    • This technique shows significant potential for imaging both perfusion and functional brain activation.
    • U-FLARE offers a promising approach for real-time neurovascular monitoring.