The epidemiology of neural tube defects. A mathematical model
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Updated: Nov 8, 2026

Monitoring the Mechanical Evolution of Tissue During Neural Tube Closure of Chick Embryo
Published on: November 10, 2023
Abstract:
The incidence of neural tube defects (NTDs) shows a seasonal variation; and incidence as well as female/male ratio show a relation with latitude. The interrelation of these phenomena is presented as a mathematical model, which has a 'predictive' value, and is an instrument in estimating the local gene frequency. The model offers a simple explanation of the conundrum why the double X-chromosome has a variable influence on the sex ratio. UV light and the herpes virus fit in this model as related causative factors of NTDs.
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