Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interactions between lipoproteins, glomerular cells and matrix

D C Wheeler1, R S Chana

  • 1Institute of Nephrology, Royal Infirmary, Cardiff, UK.

Mineral and Electrolyte Metabolism
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The effect of a novel, digital physical activity and emotional well-being intervention on health-related quality of life in people with chronic kidney disease: trial design and baseline data from a multicentre prospective, wait-list randomised controlled trial (kidney BEAM).

BMC nephrology·2023
Same author

Time-dependent lipid profile inversely associates with mortality in hemodialysis patients - independent of inflammation/malnutrition.

Journal of internal medicine·2021
Same author

A prospective study of evaluation of operative duration as a predictor of mortality in pediatric emergency surgery: Concept of 100 minutes laparotomy in resource-limited setting.

Journal of postgraduate medicine·2018
Same author

The effects of cinacalcet on blood pressure, mortality and cardiovascular endpoints in the EVOLVE trial.

Journal of human hypertension·2015
Same author

Diagnostic value of ultrasonography in evaluation and management of acute abdominal conditions in the paediatric age group.

African journal of paediatric surgery : AJPS·2012
Same author

Head and neck masses in children: A clinicopathological study.

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India·2012
Same journal

Proceedings of the 9th International Congress on Renal Nutrition and Metabolism. Vienna, Austria. August 29-September 1, 1998.

Mineral and electrolyte metabolism·2000
Same journal

Bioelectrical impedance analysis in dialysis patients.

Mineral and electrolyte metabolism·2000
Same journal

Nutritional status assessment and body composition analysis in pre-end stage renal disease patients.

Mineral and electrolyte metabolism·2000
Same journal

Long, slow dialysis.

Mineral and electrolyte metabolism·2000
Same journal

Nitric oxide/L-arginine in uremia.

Mineral and electrolyte metabolism·2000
Same journal

Advanced glycation end-product levels in subtotally nephrectomized rats: beneficial effects of angiotensin II receptor 1 antagonist losartan.

Mineral and electrolyte metabolism·2000
See all related articles

Lipid deposition and oxidation in the glomerulus promote kidney disease progression. Correcting plasma lipid abnormalities can slow the development of glomerulosclerosis and related renal injury.

Area of Science:

  • Nephrology
  • Lipid Metabolism
  • Cell Biology

Background:

  • Glomerulosclerosis involves lipid deposition, inflammation, and matrix accumulation.
  • Lipid abnormalities contribute to renal disease progression.
  • Low-density lipoprotein (LDL) plays a role in mesangial cell function.

Purpose of the Study:

  • To investigate the role of lipoproteins, particularly oxidized LDL, in glomerulosclerosis.
  • To understand how LDL affects mesangial cell proliferation and matrix production.
  • To explore the link between matrix accumulation and lipoprotein-mediated injury.

Main Methods:

  • In vitro studies using cultured mesangial cells.
  • Incubation of LDL with mesangial cells.
  • Assessment of cell proliferation, cytotoxicity, and secretory function.

Related Experiment Videos

  • Investigation of LDL oxidation effects.

    • Main Results:

    • LDL is internalized by mesangial cells and synergizes with growth factors.
    • Oxidized LDL inhibits cell proliferation and causes cytotoxic injury.
    • LDL oxidation alters mesangial cell secretory function.
    • Mesangial cell proteoglycans bind LDL, potentially worsening injury.

    Conclusions:

    • Deposited and oxidized lipoproteins in the glomerulus may drive inflammation, cell injury, and sclerosis.
    • Lipoprotein metabolism and oxidation are critical factors in glomerulosclerosis pathogenesis.
    • Targeting lipid abnormalities could be a therapeutic strategy for renal disease.