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Calcium antagonists in manic-depressive illness

S L Dubovsky1

  • 1University of Colorado School of Medicine, Denver, CO 80262.

Neuropsychobiology
|January 1, 1993
PubMed
Summary

Bipolar disorder patients show increased intracellular calcium ions when acutely ill. Calcium channel blockers like verapamil may help manage mania by modulating these calcium levels.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Cell Biology

Background:

  • Elevated free intracellular calcium ion concentration ([Ca2+]i) is observed in lymphocytes and platelets of acutely ill bipolar disorder patients.
  • Lithium therapy alters intracellular calcium dynamics and reduces platelet [Ca2+]i in affected patients.
  • Calcium ion modulation is a target for antimanic drug development.

Purpose of the Study:

  • To explore the role of calcium channel blockers (CCBs) in managing bipolar affective disorders.
  • To investigate the potential of second-generation CCBs due to their different receptor interactions.

Main Methods:

  • Review of existing research on intracellular calcium and bipolar disorder.
  • Analysis of verapamil's efficacy, particularly in lithium-responsive patients.
  • Consideration of second-generation CCBs and their distinct receptor profiles.

Main Results:

  • Verapamil, a CCB, shows efficacy, especially in patients responsive to lithium.
  • Second-generation CCBs may offer a different therapeutic spectrum due to varied receptor interactions.

Conclusions:

  • Modulating intracellular calcium ion concentration is a viable therapeutic strategy for bipolar disorder.
  • Calcium channel blockers are generally well-tolerated and may have broader applications in psychiatric, neurological, and medical conditions.

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