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Updated: Aug 9, 2026
09:03
Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye
Published on: June 20, 2015
Intraocular pressure response to scleral indentation
Summary
Scleral indentation (SI) significantly reduces intraocular pressure (IOP) immediately after the procedure. This study found a notable IOP decrease in eyes undergoing SI, highlighting its potential impact.
Area of Science:
- Ophthalmology
- Physiology
Background:
- Intraocular pressure (IOP) is a critical factor in ocular health.
- Various external and internal factors can influence IOP levels.
- Understanding immediate IOP responses to interventions is essential for clinical practice.
Purpose of the Study:
- To investigate the acute effect of scleral indentation (SI) on intraocular pressure (IOP).
- To quantify the immediate IOP changes following a standardized scleral indentation procedure.
Main Methods:
- Goldmann applanation tonometry was used to measure IOP in 25 subjects.
- IOP was recorded before and after a 40-second scleral indentation (SI) period.
- Measurements were taken in both subject eyes and control eyes under masked conditions.
Main Results:
- The subject eyes showed an average IOP decrease of 1.94 mm Hg after SI.
- Control eyes exhibited a smaller average IOP decrease of 0.52 mm Hg.
- The observed IOP reduction in subject eyes was statistically significant (p < 0.001).
Conclusions:
- Scleral indentation (SI) leads to a significant and immediate reduction in intraocular pressure (IOP).
- The findings suggest SI can acutely lower IOP, with implications for managing ocular conditions.
- A statistically significant IOP drop was confirmed in the eyes subjected to SI.
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