Chronobiology and chronotherapy of malaria: investigations with murine malaria models

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I Landau1, V Caillard, A Beaute-Lafitte

  • 1Laboratoire de Biologie Parasitaire et Chimiothérapie associé au CNRS (URA 114), Muséum National d'Histoire Naturelle, Paris, France.

Parassitologia
|July 1, 1993
PubMed

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Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...