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Naftidrofuryl treatment for rest cramp
1St Luke's Hospital, Bradford, UK.
Postgraduate Medical Journal
|August 1, 1993
Summary
Naftidrofuryl significantly reduced rest cramp frequency and increased cramp-free days in a placebo-controlled trial. This study suggests naftidrofuryl is an effective treatment for painful rest cramps.
Area of Science:
- Pharmacology
- Neurology
- Clinical Medicine
Background:
- Rest cramp is a painful condition affecting numerous individuals.
- Current treatment options for rest cramp may have limitations or side effects.
Purpose of the Study:
- To evaluate the efficacy of naftidrofuryl in treating rest cramp.
- To compare naftidrofuryl's effectiveness against a placebo.
Main Methods:
- A double-blind, placebo-controlled study was conducted.
- Fourteen subjects diagnosed with rest cramp participated in the trial.
Main Results:
- Naftidrofuryl significantly reduced the frequency of rest cramps (median 5 vs. 17, P < 0.004).
- A significant 34% increase in cramp-free days was observed with naftidrofuryl (median 22 vs. 14, P < 0.004).
Conclusions:
- Naftidrofuryl demonstrates significant efficacy in alleviating rest cramp symptoms.
- Naftidrofuryl presents a viable and effective alternative to quinine for managing rest cramp.