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[Hemifacial spasm treated with botulinum toxin]

C P Jedynak1, S Palfi, M Vidailhet

  • 1Service de Neurochirurgie du CMC Foch, Suresnes, France.

Revue Neurologique
|January 1, 1993
PubMed
Summary

Botulinum toxin injections effectively treat hemifacial spasm by blocking neuromuscular junctions. While generally safe, ptosis (droopy eyelid) is a common side effect, occurring in about 1 in 6 treatments.

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Area of Science:

  • Neurology
  • Pharmacology

Context:

  • Hemifacial spasm is a condition characterized by involuntary contractions of facial muscles.
  • Botulinum toxin is a neurotoxin that causes temporary muscle paralysis.

Purpose:

  • To evaluate the efficacy and safety of botulinum toxin injections for treating hemifacial spasm.
  • To determine the optimal injection frequency and assess treatment outcomes over a 5-year period.

Summary:

  • Fifty-four patients received repeated botulinum toxin injections for hemifacial spasm over five years, with injections administered approximately every nine weeks.
  • Nineteen patients discontinued treatment. The most frequent side effect was ptosis, observed in approximately 16.7% of injections, attributed to toxin diffusion.
  • Analysis of 42 patients showed varying degrees of improvement: 17% had no effect, 26% improved by less than 50%, 31% improved by 50-70%, and 26% improved by over 75%.

Impact:

  • Botulinum toxin injections provide a beneficial, albeit transient, therapeutic option for managing hemifacial spasm.
  • Understanding side effect profiles, such as ptosis, is crucial for patient management and optimizing treatment protocols.

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