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Related Experiment Videos

Lung involvement in rheumatoid factor-negative arthritis

O Scherak1, G Kolarz, W Popp

  • 1Institut für Rheumatologie, Kurstadt Baden, Austria.

Scandinavian Journal of Rheumatology
|January 1, 1993
PubMed
Summary

Bronchoalveolar lavage in seronegative arthritis (SNA) patients showed altered immune cells and lung tissue changes, suggesting an immunologic basis for pulmonary involvement in SNA and rheumatoid arthritis (RA).

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Area of Science:

  • Immunology
  • Rheumatology
  • Pulmonology

Background:

  • Seronegative arthritis (SNA) encompasses various conditions including psoriatic arthritis, ankylosing spondylitis, and sacroiliitis.
  • Pulmonary involvement is a recognized complication in patients with rheumatoid arthritis (RA) and other spondyloarthropathies.

Purpose of the Study:

  • To investigate pulmonary involvement in asymptomatic patients with seronegative arthritis (SNA).
  • To compare bronchoalveolar lavage (BAL) findings and lung histology in SNA patients with those in rheumatoid arthritis (RA) patients and healthy controls.

Main Methods:

  • Bronchoalveolar lavage (BAL) was performed on 13 asymptomatic SNA patients, 64 RA patients, and 15 healthy controls.
  • Transbronchial lung biopsies were obtained from 9 SNA patients and 59 RA patients.

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  • Cellular analysis of BAL fluid and histopathological examination of lung tissue were conducted.

    • Main Results:

    • BAL in SNA patients revealed decreased neutrophils and increased B-lymphocytes compared to controls.
    • Both SNA and RA patients showed increased lymphocytes (T, T-helper, activated cells); RA patients additionally had increased natural killer cells and reduced alveolar macrophages and T-suppressor cells.
    • Abnormal lung histology was observed in 4/9 SNA patients (fibrosis, lymphoid hyperplasia, pneumonitis), with similar but more pronounced findings in RA patients; differences were not statistically significant.

    Conclusions:

    • Pulmonary involvement in both SNA and RA appears to be driven by an underlying, unspecified immunologic process.
    • BAL and histology findings suggest shared immunological mechanisms contributing to lung disease in these conditions.