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Related Experiment Videos

Interaction between cholinergic and catecholaminergic agents in a spontaneous alternation task

L Kokkinidis, H Anisman

    Psychopharmacology
    |August 17, 1976
    PubMed
    Summary

    Pharmacological agents affect Y-maze spontaneous alternation. Cholinergic drugs like scopolamine impair alternation, while d-amphetamine causes perseveration, suggesting distinct neurochemical pathways influence cognitive behaviors.

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    Area of Science:

    • Neuroscience
    • Behavioral Pharmacology

    Background:

    • Spontaneous alternation in a Y-maze is a measure of exploratory behavior and working memory.
    • Pharmacological agents can significantly alter cognitive functions, including alternation behavior.

    Purpose of the Study:

    • To investigate the effects of various pharmacological agents on spontaneous alternation in a Y-maze.
    • To explore the interaction between cholinergic and catecholaminergic systems in modulating alternation and perseveration.

    Main Methods:

    • Administration of scopolamine, d-amphetamine, physostigmine, and reserpine to rodents in a free-running Y-maze task.
    • Concurrent drug administration and pre-exposure to the Y-maze were used to assess drug interactions and habituation effects.

    Main Results:

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    • Scopolamine reduced alternation to chance levels; d-amphetamine induced perseveration (alternation below chance).
    • Physostigmine increased alternation, while reserpine had no effect.
    • Reserpine reversed scopolamine's effects; physostigmine antagonized d-amphetamine's perseveration.
    • Pre-exposure enhanced d-amphetamine's effects but not scopolamine's; scopolamine augmented d-amphetamine's perseveration.

    Conclusions:

    • Cholinergic agents may influence alternation via habituation mechanisms.
    • d-amphetamine appears to induce genuine perseveration, independent of habituation.
    • Alternation and perseveration are likely mediated by the interplay between cholinergic and catecholaminergic activity.