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Summary
Scopolamine dose-dependently reduced adjunctive drinking in rats, a behavior induced by intermittent food delivery. Tolerance developed to scopolamine
Area of Science:
- Behavioral neuroscience
- Pharmacology
Background:
- Intermittent food delivery can induce adjunctive behaviors, such as drinking.
- Scopolamine is an anticholinergic drug that affects cognitive functions.
Purpose of the Study:
- To investigate the effects of scopolamine on adjunctive drinking behavior in rats.
- To examine the potential development of tolerance to scopolamine's effects on this behavior.
Main Methods:
- Food-deprived rats were exposed to intermittent food pellet delivery.
- Scopolamine (0.125-1.0 mg/kg) or physostigmine (0.2 mg/kg) was administered.
- Adjunctive drinking behavior was measured.
Main Results:
- Scopolamine administration produced a dose-related decrease in adjunctive drinking.
- Physostigmine (0.2 mg/kg) showed a slight, inconsistent reduction in drinking.
- Tolerance to the highest dose of scopolamine (1.0 mg/kg) was observed.
Conclusions:
- Scopolamine attenuates food- और water-reinforced behaviors.
- Tolerance to scopolamine's effects on adjunctive drinking can occur with repeated exposure.