Combined use of hydroxy-apatite and Tisseel in experimental bone defects in the rabbit

An experimental study in the rabbit has been undertaken to evaluate differences in bone regeneration in and around solid (Alveograf) and porous (Interpore 200) hydroxyapatite granulae. Material was placed into experimentally made bone defects and in half of the defects HA was also mixed with fibrin sealant (Tisseel). Material alone or mixed with Tisseel was also placed subperiosteally adjacent to the mandibular bone. The observation time was six months. The study showed, however, no difference in bone regeneration around solid or porous hydroxyapatite granula nor could we see differences when mixed with Tisseel or not. Implant material placed subperiosteally did not induce bone formation nor did it provoke bone resorption. The use of fibrin sealant (Tisseel) made the hydroxyapatite material much more easy to handle and to retain in the tissue.