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Updated: Aug 16, 2026

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
Comparative effect of synthetic aminoestrogens with estradiol on platelet aggregation
A De la Peña1, G Baños, R Izaguirre
1Instituto Nacional de Cardiología Ignacio Chávez, Departmento de Hemantología, México, D.F.
Abstract:
The in vitro effect upon platelet aggregation of estradiol and synthetic estrogens (prolame, buame, and proacame) is described. Prolame and buame produced a dose-dependent inhibition on platelet aggregation. Estradiol and proacame did not show anti-aggregating effects. The results suggest that the use of prolame and buame in estrogen therapy could reduce the risk of thrombo-embolic accidents.
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