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Red cell collection by apheresis technology

D Meyer1, D C Bolgiano, M Sayers

  • 1Puget Sound Blood Center, Seattle, Washington.

Transfusion
|October 1, 1993
PubMed
Summary
This summary is machine-generated.

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Apheresis red cell collection is feasible but causes more side effects than whole blood donation. Iron balance was not affected by donation method, but supplementation is crucial for non-iron-supplemented donors.

Area of Science:

  • Transfusion Medicine
  • Hematology

Background:

  • Apheresis technology allows for the collection of specific blood components.
  • Collecting 2 units (450 mL) of red cells per donation via apheresis is a potential alternative to traditional whole blood donation.

Purpose of the Study:

  • To assess the feasibility of collecting 450 mL of red cells per apheresis donation.
  • To compare apheresis red cell collection with whole blood donation in terms of donor experience and iron balance.

Main Methods:

  • A 1-year study comparing 450 mL red cell apheresis collections (3 donations) with 225 mL whole blood donations (6 occasions) in 40 donors.
  • Donors were stratified by gender and iron supplementation (ferrous gluconate vs. placebo).
  • Donor-reported symptoms, drop-out rates, hematocrit levels, serum ferritin, and red cell zinc protoporphyrin:heme ratios were monitored.

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Main Results:

  • 83% of apheresis procedures reported symptoms (numbness, tingling) compared to 0% for whole blood donations.
  • Seven donors dropped out or were deferred; fatigue was a reason for two donors.
  • No significant differences in iron balance were observed between apheresis and whole blood donation methods, though iron supplementation improved markers in non-supplemented donors.

Conclusions:

  • Collecting 450 mL of red cells via apheresis is feasible but associated with a higher incidence of transient donor symptoms.
  • Donor acceptance of apheresis was generally positive (70% acceptable).
  • Iron balance is more dependent on supplementation than donation method, highlighting the importance of iron status in frequent donors.