[Protein synthesis in tissues of guinea pigs with hypercholesterolemia]

The composition and incorporation of labelled amino acids in electrophoretic fractions of soluble proteins of the liver, brain, heart, kidneys and adrenal tissues of guinea pigs have been studied after 3 months of hypercholesterolemia. Similar quantitative changes in all the investigated tissues have been discovered as manifested by the increase of high-molecular proteins concentration and decrease of low-molecular polypeptides. The decrease of specific radioactivity of total proteins and some electrophoretic fractions has been observed under hypercholesterolemia. Only one of the fractions in the adrenals was characterized by the increase of the label incorporation level. The obtained results indicate that the long-term hypercholesterolemia is accompanied by quantitative redistribution of soluble proteins of the tissues and by suppression of their synthesis.