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[Linkage analysis in pedigrees with Alzheimer's dementia]
I Mazura1, R Jirák, F Koukolík
1Psychiatrické centrum Praha.
Vnitrni Lekarstvi
|October 1, 1993
Abstract:
Linkage analysis with three specific DNA markers was carried out on the Alzheimer's dementia pedigrees. The DNA markers used in our study, D21S1/D21S11, D21S13 and D21S16 in the 21q11.2-21q21 regions are localized. The results from different brain DNA samples and from peripheral blood samples of AD families were evaluated by two-point linkage analysis. The linkage between DNA markers and one AD pedigree was observed (D21S1/S11 and D21S13).