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Related Experiment Videos

Still's disease: experience in 12 children

Y J Wang1, Y P Lee, C S Chi

  • 1Department of Pediatrics, Taichung Veterans General Hospital, Taiwan, R.O.C.

Zhonghua Minguo Xiao Er Ke Yi Xue Hui Za Zhi [Journal]. Zhonghua Minguo Xiao Er Ke Yi Xue Hui
|September 1, 1993
PubMed
Summary

This study on Still

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Area of Science:

  • Pediatrics
  • Rheumatology
  • Immunology

Background:

  • Still's disease, a rare inflammatory condition, presents unique challenges in pediatric diagnosis and management.
  • Key clinical features include high fever, arthritis, and a characteristic rash.
  • Distinguishing Still's disease from other autoimmune conditions is crucial for effective treatment.

Purpose of the Study:

  • To describe the clinical characteristics, laboratory findings, and treatment outcomes of pediatric Still's disease.
  • To evaluate the efficacy and safety of various therapeutic interventions.
  • To assess the long-term prognosis for children diagnosed with Still's disease.

Main Methods:

  • A retrospective analysis of twelve pediatric patients diagnosed with Still's disease over a 9-year period.
  • Detailed review of clinical presentations, hemogram results, serological markers, and immunological profiles.
  • Assessment of treatment responses and adverse events associated with therapies like aspirin, NSAIDs, and corticosteroids.

Main Results:

  • Prominent symptoms included intermittent fever, poly/pauci-articular arthritis, and evanescent rash.
  • Laboratory findings revealed anemia, neutrophilic leukocytosis, thrombocytosis, elevated ferritin, CRP, and ESR.
  • Negative rheumatoid factor and ANA, but elevated IgG, IgA, complements, and immune complexes were observed.
  • Aspirin and NSAIDs were primary treatments, with 67% requiring corticosteroids; 33% used disease-modifying agents.
  • Two cases of ASA-induced liver dysfunction and one gastrointestinal bleed were noted.

Conclusions:

  • Pediatric Still's disease exhibits distinct clinical and laboratory profiles, with elevated ferritin and inflammatory markers being key indicators.
  • Combination therapy with NSAIDs and corticosteroids is often necessary for managing systemic manifestations.
  • While generally good, prognosis can be impacted by treatment complications; careful monitoring is essential.

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