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[Study on sodium norcantharidate albumin microspheres]

Y H Cheng1, G T Liao, S X Hou

  • 1School of Pharmacy, West China University of Medical Sciences, Chengdu.

Yao Xue Xue Bao = Acta Pharmaceutica Sinica
|January 1, 1993
PubMed
Summary

Sodium norcantharidate albumin microspheres (Na2NC AM) were successfully prepared and characterized. These microspheres demonstrated good stability and drug release profiles, suitable for pharmaceutical applications.

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Microsphere drug delivery systems offer controlled release and improved therapeutic efficacy.
  • Albumin microspheres are biocompatible and biodegradable carriers for various drugs.

Purpose of the Study:

  • To prepare and characterize sodium norcantharidate albumin microspheres (Na2NC AM) using an optimized procedure.
  • To evaluate the physicochemical properties, in vitro release, sterilization, and stability of the prepared Na2NC AM.

Main Methods:

  • Preparation of Na2NC AM via an optimized procedure.
  • Characterization of embedding nature, appearance, morphology, size, and size distribution.
  • In vitro drug release studies, freeze-drying, 60Co radiosterilization, and stability testing.

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Main Results:

  • Na2NC AM exhibited a mean particle size of 0.43 ± 0.12 microns.
  • Achieved an embedding concentration of 20.34–26.75 µg/mg and an embedding ratio of 21.9–26.4%.
  • In vitro release followed Higuchi kinetics; freeze-drying and radiosterilization had no adverse effects; good stability was observed over 3 months.

Conclusions:

  • Optimized preparation yielded stable Na2NC AM with desirable characteristics for drug delivery.
  • The microspheres are suitable for freeze-drying and sterilization, indicating good processability.
  • Na2NC AM show potential as a viable drug delivery system with sustained release properties.