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Immune alterations in chronic morphine-treated rhesus monkeys
1Department of Microbiology, LSU Medical Center, New Orleans 70112-1393.
Advances in Experimental Medicine and Biology
|January 1, 1993
Summary
Morphine exposure alters immune cells in rhesus monkeys, affecting T-cell populations and cyclic AMP (cAMP) production. These findings in monkeys mirror human opioid abuse effects, suggesting a valuable model for studying opioid impacts on immunity.
Area of Science:
- Immunology
- Neuroendocrinology
- Pharmacology
Background:
- Opioid abuse is linked to immune and neuroendocrine system abnormalities.
- Understanding these effects is crucial for developing effective treatments.
Purpose of the Study:
- To investigate the impact of morphine exposure on immunocompetence in rhesus monkeys.
- To establish a relevant animal model for studying opioid effects on the immune system.
Main Methods:
- Rhesus monkeys were divided into drug-naive, infrequent morphine, and daily morphine groups.
- Peripheral blood mononuclear cells (PBMs) were analyzed for lymphocyte percentages (CD4+, CD8+).
- Cellular response to forskolin, measuring cyclic AMP (cAMP) production, was assessed.
Main Results:
- Morphine exposure decreased CD4+ and increased CD8+ lymphocytes.
- Daily morphine increased helper-inducer CD4+ lymphocytes (CD4+CD29+).
- Daily morphine exposure impaired cAMP production in response to forskolin, while infrequent exposure elevated it.
Conclusions:
- Even low doses of morphine significantly affect rhesus monkey immunocompetence.
- These effects parallel those seen in opioid-dependent humans.
- Rhesus monkeys serve as a valuable model for studying opioid-related immune modulation.