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Related Experiment Videos

Multiple sclerosis presenting as Parinaud syndrome

D J Quint1, W T Cornblath, J D Trobe

  • 1Department of Radiology, University of Michigan Hospitals, Ann Arbor 48109-0030.

AJNR. American Journal of Neuroradiology
|September 1, 1993
PubMed
Summary
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Multiple sclerosis can initially manifest as Parinaud syndrome, characterized by paralysis of upward gaze. Ruling out midbrain lesions is crucial when screening studies do not reveal a pineal or third ventricle mass.

Area of Science:

  • Neurology
  • Neuro-ophthalmology
  • Demyelinating Diseases

Background:

  • Demyelinating diseases, such as multiple sclerosis, can present with diverse neurological symptoms.
  • Parinaud syndrome, or paralysis of upward gaze, is a rare initial presentation.

Observation:

  • A patient presented with a one-week history of paresis of upward gaze.
  • This paresis was the initial manifestation of an underlying demyelinating disease.

Findings:

  • Multiple sclerosis should be considered in the differential diagnosis of Parinaud syndrome.
  • It is essential to exclude non-contour-deforming intraaxial midbrain lesions.

Implications:

  • Early recognition of demyelinating disease presenting as Parinaud syndrome is vital for timely diagnosis and treatment.

Related Experiment Videos

  • Neuroimaging is critical to differentiate demyelinating lesions from other midbrain pathologies.