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Related Experiment Videos

Complement activity in children with protein-calorie malnutrition

R Suskind, R Edelman, P Kulapongs

    The American Journal of Clinical Nutrition
    |October 1, 1976
    PubMed
    Summary

    Children with severe protein calorie malnutrition (PCM) show impaired complement system function, indicated by low hemolytic complement (CH50) activity. Nutritional recovery restores CH50 levels, suggesting diet is crucial for immune system repair.

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    Area of Science:

    • Immunology
    • Nutritional Science
    • Pediatrics

    Background:

    • The complement system is a critical part of innate immunity.
    • Severe protein calorie malnutrition (PCM) can impact immune function.
    • Hemolytic complement (CH50) activity is a measure of complement system integrity.

    Purpose of the Study:

    • To evaluate the complement system's hemolytic complement (CH50) activity in children with severe PCM.
    • To assess changes in CH50 activity during hospital admission and recovery.
    • To investigate the presence of anticomplementary (AC) activity in PCM patients.

    Main Methods:

    • Utilized the hemolytic complement (CH50) assay.
    • Monitored 28 children with severe PCM during hospitalization and recovery.

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  • Compared CH50 activity with 17 healthy control subjects.
  • Assessed serum anticomplementary (AC) activity.

    • Main Results:

    • Children with kwashiorkor had significantly lower CH50 activity on hospital days 1 and 4 compared to controls.
    • CH50 activity normalized by day 8 and became significantly higher than controls by day 50.
    • 40% of PCM children showed anticomplementary (AC) activity, which decreased significantly during recovery.
    • A significant inverse correlation was found between CH50 titer and AC activity in PCM serum.

    Conclusions:

    • The complement system is functionally compromised in children with severe PCM.
    • Adequate dietary intake is essential for the repair of complement system function.
    • Anticomplementary activity may contribute to depressed complement function in untreated PCM.