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Intraocular irrigating solutions and lens clarity
American Journal of Ophthalmology
|October 1, 1976
Summary
New intraocular irrigating solutions, prepared by adding dextrose and sodium bicarbonate to Ringer's solutions, offer improved lens clarity during surgery. These easily prepared mixtures may enhance surgical outcomes for prolonged intraocular irrigation procedures.
Area of Science:
- Ophthalmology
- Biochemistry
Background:
- Intraocular irrigating solutions are crucial for maintaining lens clarity during ophthalmic surgery.
- Current clinical solutions may not offer optimal protection for prolonged procedures.
Purpose of the Study:
- To evaluate novel intraocular irrigating solutions prepared by combining commercially available dextrose 5% in water and sodium bicarbonate with Ringer's injection or Ringer's lactate.
- To assess the efficacy of these new solutions in maintaining lens clarity in vitro.
Main Methods:
- Rhesus monkey lenses were incubated in vitro at 37°C.
- Aseptically prepared mixtures of dextrose 5% in water and sodium bicarbonate with Ringer's injection or Ringer's lactate were used as irrigating solutions.
Main Results:
- The novel mixtures demonstrated superiority over standard intraocular irrigating solutions in maintaining lens clarity.
- While not as effective as glutathione-bicarbonate-Ringer's solution (G-B-R), these new solutions are easily prepared in the operating room.
Conclusions:
- Easily prepared intraocular irrigating solutions can be formulated using dextrose and sodium bicarbonate with Ringer's-based solutions.
- These novel solutions show potential for improving surgical outcomes in procedures requiring extended intraocular irrigation.