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Related Experiment Videos

Elevation of plasma renin activity during avoidance performance in baboons

M L Blair, E O Feigl, O A Smith

    The American Journal of Physiology
    |September 1, 1976
    PubMed
    Summary

    Psychological stress from operant conditioning significantly elevates plasma renin activity in baboons. This study shows that even without direct physical harm, mental challenges can impact physiological responses like renin levels.

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    Area of Science:

    • Physiology
    • Behavioral Neuroscience
    • Endocrinology

    Background:

    • The renin-angiotensin-aldosterone system (RAAS) plays a crucial role in regulating blood pressure and fluid balance.
    • Psychological stressors are known to influence various physiological systems, but their specific impact on the RAAS requires further elucidation.

    Purpose of the Study:

    • To investigate the effect of a Sidman avoidance operant conditioning schedule on plasma renin activity and renin substrate concentration in baboons.
    • To determine if psychological stimuli can modulate key components of the RAAS.

    Main Methods:

    • Baboons (Papio cynocephalus) were subjected to a 3-hour Sidman avoidance operant conditioning schedule (lever pressing to avoid electric shock).
    • Plasma samples were collected over a 24-hour period on both control and test days.

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  • Plasma renin activity and renin substrate concentration were measured.

    • Main Results:

    • Plasma renin activity was significantly elevated at 1, 2, and 3 hours after the start of the avoidance test, and 30 minutes after its termination, compared to control periods (P = .032).
    • The increase in plasma renin activity did not correlate with the rate of lever pressing or the number of shocks received.
    • Renin substrate concentration remained unchanged throughout the study.

    Conclusions:

    • Psychological stimuli, such as those encountered during operant conditioning, can increase plasma renin activity.
    • These findings suggest a direct link between psychological stress and the activation of the renin-angiotensin system.