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Related Experiment Videos

Lead and hyperactivity. Behavioral response to chelation: a pilot study

O J David, S P Hoffman, J Sverd

    The American Journal of Psychiatry
    |October 1, 1976
    PubMed
    Summary
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    Elevated lead levels may contribute to hyperactivity in some children. Lead-chelating medication showed significant improvement in children with unremarkable histories, suggesting lead

    Area of Science:

    • Environmental Health
    • Pediatric Neurology
    • Toxicology

    Background:

    • Hyperactivity is a common behavioral disorder in children.
    • The role of environmental factors, such as lead exposure, in hyperactivity is under investigation.
    • Elevated lead levels, even if considered "nontoxic," may have subtle neurodevelopmental effects.

    Purpose of the Study:

    • To investigate the efficacy of lead-chelating medication in treating hyperkinetic school children.
    • To explore the potential role of lead exposure in the etiology of hyperactivity.
    • To determine if prior developmental complications influence treatment response.

    Main Methods:

    • Treatment of 13 hyperkinetic school children with lead-chelating medication.
    • Assessment of blood and urine lead levels.

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  • Evaluation of treatment response based on medical history, particularly perinatal and developmental complications.

    • Main Results:

    • Seven children with unremarkable histories showed marked improvement with lead-chelating therapy.
    • Six children with histories of perinatal or developmental complications showed limited improvement.
    • This suggests a correlation between lead exposure and hyperactivity, particularly in cases without other known etiological factors.

    Conclusions:

    • Lead may be a significant etiological factor in some cases of childhood hyperactivity.
    • Lead-chelating agents show promise as a treatment modality for hyperactivity.
    • Medical evaluations for hyperactivity should include lead level testing and consideration of environmental factors.