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Related Experiment Videos

Dynamic, short-term coupling between changes in arterial pressure and urine flow

J E Steele1, P H Brand, P J Metting

  • 1Department of Physiology and Biophysics, Medical College of Ohio, Toledo 43699.

The American Journal of Physiology
|November 1, 1993
PubMed
Summary

This study found that changes in arterial pressure (AP) directly impact urine flow (UF) within seconds. The urinary system responds rapidly, with urine flow changing approximately 6 seconds after arterial pressure alterations.

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Area of Science:

  • Physiology
  • Renal Physiology

Background:

  • Pressure diuresis is the direct effect of arterial pressure (AP) on urine flow (UF).
  • Computer models suggest pressure diuresis is a long-term mechanism regulating blood volume and AP.
  • Limited in vivo data exists on the speed of AP-induced UF changes.

Purpose of the Study:

  • To systematically measure the rapidity of urine flow response to acute changes in arterial pressure in vivo.
  • To determine the delay between induced AP changes and subsequent UF alterations.

Main Methods:

  • Anesthetized rats were instrumented for continuous measurement of AP and UF.
  • Acute AP changes were induced via aortic occlusion, tail pinch, or vasoactive drug administration (acetylcholine, phenylephrine, angiotensin II).
  • The delay between significant AP changes and UF changes was calculated.

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Main Results:

  • The average delay between induced arterial pressure changes and subsequent urine flow response was 6.0 ± 0.5 seconds.
  • An exponential relationship was observed between AP and UF, with UF changes being disproportionately larger than AP changes (up to 10x).

Conclusions:

  • The renal response to arterial pressure fluctuations is rapid, occurring within seconds.
  • Arterial pressure exerts a potent, non-linear influence on urine flow rate.