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Sustained sleep deprivation impairs host defense

C A Everson1

  • 1Clinical Psychobiology Branch, National Institute of Mental Health, Bethesda, Maryland 20892.

The American Journal of Physiology
|November 1, 1993
PubMed
Summary

Prolonged sleep deprivation in rats leads to a hypercatabolic state and mortality. This study reveals it

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Area of Science:

  • Neuroscience
  • Immunology
  • Physiology

Background:

  • Prolonged sleep deprivation in rats induces a hypercatabolic state, malnutrition, and mortality.
  • The underlying cause of this vital impairment remains largely unknown.
  • Previous investigations found no significant metabolic, clinical, or hematological abnormalities.

Purpose of the Study:

  • To determine the nature of the vital impairment caused by prolonged sleep deprivation.
  • To elucidate the organic dysfunction that sleep normally prevents.
  • To investigate the potential role of the immune system in sleep deprivation-induced mortality.

Main Methods:

  • Rats were subjected to prolonged sleep deprivation.
  • Comprehensive analyses of intermediary metabolism, clinical chemistry, and hematology were performed.
  • Postmortem examinations, including morphological and histopathological assessments, were conducted.
  • Blood cultures were analyzed for microbial invasion.

Main Results:

  • No gross disturbances in metabolism, clinical chemistry, or hematology were detected.
  • Postmortem examinations showed no systematic morphological or histopathological findings.
  • Blood cultures revealed invasion by opportunistic microbes without a febrile response.
  • Cachexia was observed in the absence of structural organ damage.

Conclusions:

  • The findings suggest a breakdown in host defense mechanisms against microorganisms.
  • Prolonged sleep deprivation appears to compromise the immune system's ability to combat infections.
  • This immune system failure is implicated as the cause of mortality in sleep-deprived rats.

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