Related Experiment Videos
Vasodilator effects of hydroxylamine in the isolated rodent lung
E C Santoian1, G Thomas, A D Angerio
1Department of Physiology and Biophysics, Georgetown University Medical Center, Washington, D.C.
Angiology
|November 1, 1993
Abstract:
Hydroxylamine is a natural product of cellular metabolism that possesses vasodilating properties similar to those of endothelium-derived relaxing factor (EDRF). In the rodent pulmonary circulation preconstricted with the endoperoxide analog U-46619, hydroxylamine relaxed the vasculature in a concentration-dependent manner. Blockade of the hydroxylamine vasodilator response by methylene blue indicated that the mechanism of vasorelaxation is similar to that of EDRF. In this preparation, hydroxylamine is a more potent vasodilator than nitroglycerin.