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Related Experiment Videos

Changes in serum catecholamine levels during acute bronchospasm

C L Emerman1, R K Cydulka

  • 1Department of Emergency Medicine, MetroHealth Medical Center, Cleveland, Ohio.

Annals of Emergency Medicine
|December 1, 1993
PubMed
Summary

Acute asthma and COPD do not significantly increase epinephrine levels, suggesting moderate bronchospasm is insufficient to stimulate its release. Norepinephrine levels were higher in COPD patients.

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Area of Science:

  • Pulmonary Medicine
  • Endocrinology
  • Emergency Medicine

Background:

  • Norepinephrine levels rise in acute asthma, but epinephrine levels remain normal.
  • It is unclear if this is due to a secretion defect or insufficient stimulus in asthmatics.

Purpose of the Study:

  • To investigate if asthmatics have an inherent defect in catecholamine secretion.
  • To determine if insufficient stimulus causes the lack of epinephrine release in asthmatics.

Main Methods:

  • Prospective study in an emergency department.
  • Included patients over 18 with acute asthma or COPD exacerbation.
  • Measured catecholamine levels and spirometry before and after treatment with bronchodilators and steroids for asthma.

Main Results:

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  • No difference in epinephrine levels between asthma and COPD patients pre- or post-treatment.
  • Norepinephrine levels were higher in COPD patients.
  • Weak correlation between epinephrine and FEV1 in asthma, none in COPD.

Conclusions:

  • Moderate bronchospasm is not a significant stimulus for epinephrine release in acute asthma or COPD.
  • The findings suggest a potential difference in catecholamine response between asthma and COPD.