Related Experiment Video
Updated: Jul 16, 2026

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
Published on: June 7, 2015
Treatment of foxglove extract poisoning with digoxin-specific Fab fragments
S A Rich1, J M Libera, R J Locke
1Pharmacy and Therapeutics Committee, FF Thompson Hospital, Canandaigua, New York.
Abstract:
A 22-year-old man presented to our emergency department after an intentional overdose of a homemade foxglove extract. Clinical symptoms with symptomatic bradyarrhythmia and ECG changes were consistent with cardiac glycoside poisoning. Treatment with digoxin-specific Fab fragments resulted in transient clinical and ECG improvement. Serum immunoassay demonstrated a digitoxin-like glycoside. The serum levels showed no evidence of altered elimination or distribution with Fab therapy despite temporary improvements in the clinical course. The use of Fab did not result in a shortened clinical course in this episode of foxglove poisoning, as one would expect in the setting of commercial glycoside product poisoning.
Related Concept Videos
Prevention of Further Absorption of Poison
Anticholinesterase Agents: Poisoning and Treatment
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is slower than the...
Heart Failure Drugs: Inotropic Agents
Pharmaceutical Poisoning: Treatment Strategies
Cardiopulmonary Resuscitation IV: Pharmacological Management

