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Microbial conversion of avermectins by Saccharopolyspora erythraea: glycosylation at C-4' and C-4''
M Schulman1, P Doherty, B Arison
1Merck Research Laboratories, Rahway, New Jersey 07065.
Antimicrobial Agents and Chemotherapy
|September 1, 1993
Abstract:
Avermectins and ivermectins are glycosylated at C-4'' and C-4' by both growing and resting cells of Saccharopolyspora erythraea. The reaction is catalyzed by a glycosyltransferase which is constitutive. The enzyme uses UDP-glucose as the glycosyl donor and avermectin or ivermectin mono- and disaccharides as acceptors. Avermectin and ivermectin aglycones and erythromycin A are not substrates for the enzyme.