Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gene delivery systems in surgery

H K Lyerly1, J M DiMaio

  • 1Department of Surgery, Duke University Medical Center, Durham, NC.

Archives of Surgery (Chicago, Ill. : 1960)
|November 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Combination of DC/CIK adoptive T cell immunotherapy with chemotherapy in advanced non-small-cell lung cancer (NSCLC) patients: a prospective patients' preference-based study (PPPS).

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·2018
Same author

Prospective study of cyclophosphamide, thiotepa, carboplatin combined with adoptive DC-CIK followed by metronomic cyclophosphamide therapy as salvage treatment for triple negative metastatic breast cancers patients (aged <45).

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·2015
Same author

Depleting regulatory T cells with arginine-rich, cell-penetrating, peptide-conjugated morpholino oligomer targeting FOXP3 inhibits regulatory T-cell function.

Cancer gene therapy·2011
Same author

Donor-transmitted malignancies in organ transplantation: assessment of clinical risk.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2011
Same author

Targeting GLI1 expression in human inflammatory breast cancer cells enhances apoptosis and attenuates migration.

British journal of cancer·2011
Same author

ADAM metallopeptidase domain 17 (ADAM17) is naturally processed through major histocompatibility complex (MHC) class I molecules and is a potential immunotherapeutic target in breast, ovarian and prostate cancers.

Clinical and experimental immunology·2010
Same journal

The White Test: A New Dye Test for Intraoperative Detection of Bile Leakage During Major Liver Resection-Invited Critique.

Archives of surgery (Chicago, Ill. : 1960)·2017
Same journal

Use of Vascular Clamping in Hepatic Surgery: Lessons Learned From 1260 Liver Resections-Invited Critique.

Archives of surgery (Chicago, Ill. : 1960)·2017
Same journal

Randomized Clinical Trial of Small-Incision and Laparoscopic Cholecystectomy in Patients With Symptomatic Cholecystolithiasis: Primary and Clinical Outcomes-Invited Critique.

Archives of surgery (Chicago, Ill. : 1960)·2017
Same journal

Liver Resection With a New Multiprobe Bipolar Radiofrequency Device-Invited Critique.

Archives of surgery (Chicago, Ill. : 1960)·2017
Same journal

Porcine and Bovine Surgical Products: Jewish, Muslim, and Hindu Perspectives-Invited Critique.

Archives of surgery (Chicago, Ill. : 1960)·2017
Same journal

Neuroendocrine Liver Metastasis: Transplant as Part of Multimodality Liver-Directed Therapy-Reply.

Archives of surgery (Chicago, Ill. : 1960)·2016
See all related articles

Gene therapy offers potential for human diseases, but efficient gene delivery and expression in target cells remain critical challenges for widespread clinical use.

Area of Science:

  • Biomedical science
  • Genetics
  • Molecular biology

Background:

  • Advances in understanding human disease genetics.
  • Emergence of gene-based therapies.
  • In vitro gene delivery methods developed.

Purpose of the Study:

  • To review the potential of gene-based therapies.
  • To highlight challenges in gene delivery for clinical applications.
  • To identify areas for technological development.

Main Methods:

  • Literature review of gene therapy research.
  • Analysis of gene transfer and expression technologies.
  • Discussion of in vitro and in vivo delivery methods.

Main Results:

Related Experiment Videos

  • Gene-based therapies show promise for various disorders.
  • Efficient gene delivery to target cells is a major research focus.
  • Optimizing gene transfer and expression requires further technological advancement.

Conclusions:

  • Gene therapy holds significant clinical potential.
  • Overcoming technical hurdles in gene delivery and expression is crucial.
  • Future technological developments are essential for widespread gene therapy implementation.