Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Growth factors. Local and systemic

D N Herndon1, T T Nguyen, D A Gilpin

  • 1Shriners Burns Institute, Galveston.

Archives of Surgery (Chicago, Ill. : 1960)
|November 1, 1993
PubMed
Summary

Growth factors are key to wound healing, influencing cell behavior locally and systemically. Clinical trials show these factors, like growth hormone and epidermal growth factor, improve healing outcomes, especially in complex patient cases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The role of bone densitometry in the diagnosis and management of the severely burned patient with bone loss.

Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry·2013
Same author

The effect of obesity on adverse outcomes and metabolism in pediatric burn patients.

International journal of obesity (2005)·2011
Same author

Pre-clinical evaluation of liposomal gene transfer to improve dermal and epidermal regeneration.

Gene therapy·2010
Same author

[Pathophysiology of acute lung injury in severe burn and smoke inhalation injury].

Der Anaesthesist·2009
Same author

The combination of IGF-I and KGF cDNA improves dermal and epidermal regeneration by increased VEGF expression and neovascularization.

Gene therapy·2007
Same author

Beta-blockade in burns.

Novartis Foundation symposium·2007

Area of Science:

  • Biochemistry
  • Cell Biology
  • Regenerative Medicine

Background:

  • Growth factors are signaling proteins crucial for cellular processes.
  • Wound healing involves complex interactions of local and systemic growth factors.
  • Understanding these interactions is vital for therapeutic advancements.

Purpose of the Study:

  • To explore the dual role of local and systemic growth factors in wound healing.
  • To investigate the mechanisms of growth factor action via cell-surface receptors.
  • To highlight the therapeutic potential of growth factors in clinical settings.

Main Methods:

  • Review of existing literature on growth factor roles in wound repair.
  • Analysis of cellular responses to various growth factors (e.g., growth hormone, EGF, FGF, PDGF, TGF-β).
  • Examination of clinical trial data on growth factor efficacy.

Main Results:

  • Growth factors can have stimulatory or inhibitory effects based on cellular context.
  • Specific growth factors like growth hormone, EGF, FGF, PDGF, and TGF-β enhance wound healing.
  • Growth factors play a significant role in healing for catabolic, malnourished, and cancer patients.

Conclusions:

  • Growth factors are essential mediators of wound healing.
  • Their therapeutic application shows promise for improving patient outcomes.
  • Further clinical trials may establish growth factors as standard therapy.

Related Experiment Videos