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Phosphocitrate prevents disease progression in murine progressive ankylosis
H E Krug1, M L Mahowald, P B Halverson
1Department of Medicine, Minneapolis Veterans Affairs Medical Center.
Objective:
Mice with progressive ankylosis, a spontaneous arthropathy, were treated with phosphocitrate (PC) in vivo to determine the effect of PC on disease progression.
Methods:
Two groups of mice with progressive ankylosis (matched for age, weight, and sex) were treated parenterally for 6 weeks with either PC or saline vehicle.
Results:
Clinically, histologically, and microradiographically, there were significant differences in disease progression and severity in the PC-treated and the saline-treated mice.
Conclusion:
PC appears to inhibit disease progression in murine progressive ankylosis.
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