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Related Experiment Videos

Neural modulation of bovine mesenteric lymph node contraction

G A Hughes1, J M Allen

  • 1Biomedical Sciences Research Centre, University of Ulster, Coleraine.

Experimental Physiology
|September 1, 1993
PubMed
Summary

Bovine mesenteric lymph node capsule smooth muscle contracts when stimulated. These contractions are mediated by nerves that are not adrenergic, cholinergic, or purinergic, suggesting a novel pathway for lymph node function.

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Area of Science:

  • Immunology
  • Physiology
  • Neuroscience

Background:

  • The mesenteric lymph node capsule contains smooth muscle.
  • The innervation and contractile mechanisms of this smooth muscle are not well understood.

Purpose of the Study:

  • To investigate the innervation and contractile properties of bovine mesenteric lymph node capsular smooth muscle in vitro.

Main Methods:

  • Isometric contractions and field-evoked responses were recorded from bovine mesenteric lymph node capsule strips.
  • The effects of various neurotoxins and receptor antagonists (tetrodotoxin, adrenoceptor antagonists, atropine, cocaine, alpha,beta-methylene ATP) were assessed.

Main Results:

  • Field stimulation evoked frequency-dependent contractions, maximal at frequencies >= 16 Hz.

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  • Contractions were significantly reduced by tetrodotoxin, indicating neural involvement.
  • Responses were unaffected by adrenergic, cholinergic, or purinergic antagonists, as well as cocaine and alpha,beta-methylene ATP.

    • Conclusions:

    • Bovine mesenteric lymph node capsular smooth muscle is innervated by excitatory nerves.
    • These nerves are non-adrenergic, non-cholinergic, and non-purinergic.
    • This suggests a novel neurotransmitter system involved in lymph node capsule contractility.