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Renal blood flow in obstructive jaundice: an experimental study in baboons
Clinical and Experimental Pharmacology & Physiology
|September 1, 1976
Summary
Obstructive jaundice in baboons alters kidney blood flow, shifting it from the cortex to the juxtamedullary region. This change is linked to increased renovascular sensitivity to catecholamines, specifically via alpha-adrenoceptor activity.
Area of Science:
- Nephrology
- Physiology
- Pharmacology
Background:
- Obstructive jaundice can significantly impact organ function.
- Renal blood flow dynamics are crucial for kidney health.
- Understanding alterations in renal perfusion is vital for managing complications.
Purpose of the Study:
- To investigate the effects of obstructive jaundice on intrarenal blood flow distribution in baboons.
- To determine the role of catecholamines and adrenoceptor activity in these circulatory changes.
Main Methods:
- 133Xe-washout technique was used to measure intrarenal blood flow in baboon models.
- Comparison between baboons with ligated bile ducts and sham-operated controls.
- Infusion of noradrenaline and administration of alpha- and beta-adrenoceptor blocking agents.
Main Results:
- Obstructive jaundice led to decreased cortical blood flow and increased juxtamedullary flow.
- Baboons with jaundice exhibited an enhanced pressor response to noradrenaline.
- This enhanced response was abolished by alpha-adrenoceptor blockade (phenoxybenzamine) but not beta-blockade (propranolol).
Conclusions:
- Obstructive jaundice induces significant alterations in renal perfusion patterns.
- Increased renovascular sensitivity to catecholamines, mediated by enhanced alpha-adrenoceptor activity, is implicated.
- Findings suggest a mechanism for renal dysfunction in obstructive jaundice.