Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Synthesis and characterization of putrescine-based poly(phosphoester-urethanes)

B I Dahiyat1, E Hostin, E M Posadas

  • 1Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218.

Journal of Biomaterials Science. Polymer Edition
|January 1, 1993
PubMed
Summary

Novel degradable poly(phosphoester-urethanes) were synthesized for biomaterial applications. Their degradation rate and drug release capabilities were modulated by incorporating specific phosphoester diols.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deep androgen receptor suppression in prostate cancer exploits sexually dimorphic renal expression for systemic glucocorticoid exposure.

Annals of oncology : official journal of the European Society for Medical Oncology·2020
Same author

Real-time observation of leukocyte-endothelium interactions in tissue-engineered blood vessel.

Lab on a chip·2018
Same author

High-throughput screening of microchip-synthesized genes in programmable double-emulsion droplets.

Nanoscale·2017
Same author

Stromal fibroblast-derived miR-409 promotes epithelial-to-mesenchymal transition and prostate tumorigenesis.

Oncogene·2014
Same author

Chemical modification of collagen improves glycosaminoglycan retention of their co-precipitates.

Acta biomaterialia·2012
Same author

A randomized, phase II study of pazopanib in castrate-sensitive prostate cancer: a University of Chicago Phase II Consortium/Department of Defense Prostate Cancer Clinical Trials Consortium study.

Prostate cancer and prostatic diseases·2011

Area of Science:

  • Polymer Chemistry
  • Biomaterials Science
  • Materials Engineering

Background:

  • Segmented polyurethanes are widely used in biomedical applications.
  • Developing degradable polyurethanes with tunable properties is crucial for advanced biomaterials.
  • Phosphoester bonds offer a potential pathway for controlled hydrolytic degradation.

Purpose of the Study:

  • To synthesize and characterize novel putrescine-based poly(phosphoester-urethanes) (PPU).
  • To evaluate the hydrolytic degradation behavior of these PPUs in vitro.
  • To assess the potential for drug attachment and release from the PPU backbone.

Main Methods:

  • Synthesis of PPUs using 1,4-butane-diisocyanate and phosphoester diols (BGP, BHP).
  • Characterization of mechanical properties (UTS, elongation) and viscoelasticity (tan delta).

Related Experiment Videos

  • In vitro hydrolytic degradation studies (mass loss, GPC) and drug release assays.

    • Main Results:

    • Synthesized flexible PPUs with UTS of 2-3 MPa and elongation up to 80%.
    • Incorporation of phosphoester bonds enabled tunable hydrolytic degradation, modulated by BGP content and hydrophobicity (BHP).
    • Demonstrated successful pendant attachment and release of PAS drug (approx. 5 h).

    Conclusions:

    • Putrescine-based PPUs are promising degradable biomaterials with tunable properties.
    • The phosphoester linkage allows for controlled degradation and potential for drug delivery systems.
    • Further research can optimize PPU for specific biomedical applications based on degradation and drug release profiles.