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Synthesis and characterization of putrescine-based poly(phosphoester-urethanes)
B I Dahiyat1, E Hostin, E M Posadas
1Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218.
Journal of Biomaterials Science. Polymer Edition
|January 1, 1993
Summary
Novel degradable poly(phosphoester-urethanes) were synthesized for biomaterial applications. Their degradation rate and drug release capabilities were modulated by incorporating specific phosphoester diols.
Area of Science:
- Polymer Chemistry
- Biomaterials Science
- Materials Engineering
Background:
- Segmented polyurethanes are widely used in biomedical applications.
- Developing degradable polyurethanes with tunable properties is crucial for advanced biomaterials.
- Phosphoester bonds offer a potential pathway for controlled hydrolytic degradation.
Purpose of the Study:
- To synthesize and characterize novel putrescine-based poly(phosphoester-urethanes) (PPU).
- To evaluate the hydrolytic degradation behavior of these PPUs in vitro.
- To assess the potential for drug attachment and release from the PPU backbone.
Main Methods:
- Synthesis of PPUs using 1,4-butane-diisocyanate and phosphoester diols (BGP, BHP).
- Characterization of mechanical properties (UTS, elongation) and viscoelasticity (tan delta).
- In vitro hydrolytic degradation studies (mass loss, GPC) and drug release assays.
Main Results:
- Synthesized flexible PPUs with UTS of 2-3 MPa and elongation up to 80%.
- Incorporation of phosphoester bonds enabled tunable hydrolytic degradation, modulated by BGP content and hydrophobicity (BHP).
- Demonstrated successful pendant attachment and release of PAS drug (approx. 5 h).
Conclusions:
- Putrescine-based PPUs are promising degradable biomaterials with tunable properties.
- The phosphoester linkage allows for controlled degradation and potential for drug delivery systems.
- Further research can optimize PPU for specific biomedical applications based on degradation and drug release profiles.