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Updated: Aug 13, 2026

Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions
Published on: March 12, 2019
The effect of TRH on the anterior pituitary adenylate-cyclase activity of rat
Abstract:
Synthetic thyrotropin releasing hormone was found to stimulate rat anterior pituitary adenylate cyclase activity. In the presence of guanosine triphosphate, no further stimulation was recorded; guanosine triphosphate alone also increased the adenylate cyclase activity. Prostaglandin E1 was found to stimulate a basal enzyme activity and this effect was significantly enhanced by guanosine triphosphate. It appears that guanosine triphosphate could be a modulator of adenylate cyclase activity in rat anterior pituitary in response to PGE1 but not to TRH.
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