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Structure and expression of the mouse testicular H1 histone gene (H1t)
B Drabent1, C Bode, D Doenecke
1Institut für Biochemie und Molekulare Zellbiologie, Georg-August-Universität, Göttingen, Germany.
Biochimica Et Biophysica Acta
|November 16, 1993
Abstract:
A mouse genomic library was screened with a human testicular H1 (H1t) gene fragment. One phage containing the testis specific mouse H1t histone gene and its flanking regions was isolated. Northern blot analysis showed that the mouse H1t gene is expressed only in mouse testis at the stage of pachytene spermatocytes and that the H1t mRNA is not polyadenylated. This mouse H1t gene encodes a protein which differs from the somatic mouse H1 proteins, but is similar to the known H1t proteins from rat, and man.