Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Short-term clinical study with bicarbonate-containing peritoneal dialysis solution

M Feriani1, D Dissegna, G La Greca

  • 1Department of Nephrology, St. Bortolo Hospital, Vicenza, Italy.

Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis
|January 1, 1993
PubMed
Summary

This study shows that a new bicarbonate solution for continuous ambulatory peritoneal dialysis (CAPD) effectively corrects uremic acidosis without compromising dialysis adequacy or patient safety. The bicarbonate CAPD solution is safe and well-tolerated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation and management of chronic anorectal and pelvic pain syndromes: Italian Society of Colorectal Surgery (SICCR) position statement.

Techniques in coloproctology·2024
Same author

Characterization of resistance to pirimiphos-methyl (an organophosphate insecticide) in Culex pipiens pipiens (Diptera: Culicidae) from Northern and Southern Tunisia.

Tropical biomedicine·2021
Same author

Multiple resistance mechanisms associated with low pirimifos-methyl resistance in Culex pipiens pipiens in three populations of Tunisia.

Tropical biomedicine·2021
Same author

Impacts of agricultural practices on pyrethroid resistance in Culex pipiens pipiens, an important vector of human diseases, from Tunisia.

Tropical biomedicine·2021
Same author

Acute acalculous cholecystitis on a COVID-19 patient: a case report.

Annals of medicine and surgery (2012)·2020
Same author

Cystic pancreatic tumors: should we resect all of them?

European review for medical and pharmacological sciences·2014

Area of Science:

  • Nephrology
  • Biochemistry

Background:

  • Continuous ambulatory peritoneal dialysis (CAPD) is a vital treatment for end-stage renal disease.
  • Managing acid-base balance in CAPD patients, particularly uremic acidosis, remains a clinical challenge.
  • Lactate-based solutions are standard but can be less effective in correcting acidosis.

Purpose of the Study:

  • To evaluate a novel bicarbonate-based CAPD solution for efficacy, adequacy, clinical tolerance, and safety.
  • To assess the impact of bicarbonate CAPD on acid-base balance and key dialysis parameters.
  • To investigate the potential for precipitation issues with bicarbonate and calcium in CAPD solutions.

Main Methods:

  • A 6-week cross-over study involving 6 stable CAPD patients.
  • Patients initially received a standard lactate solution, followed by a 4-week period with a novel two-chamber bicarbonate-calcium CAPD solution.

Related Experiment Videos

  • The two-chamber system allowed mixing of bicarbonate and calcium just before use to prevent precipitation.

    • Main Results:

    • Blood bicarbonate levels significantly increased, indicating effective correction of uremic acidosis.
    • No significant changes were observed in key dialysis adequacy markers (BUN, creatinine) or electrolytes.
    • Peritoneal clearances remained constant due to a balance between slightly reduced solute transport and increased ultrafiltration; no adverse effects were reported.

    Conclusions:

    • The bicarbonate CAPD solution is effective for correcting uremic acidosis in CAPD patients.
    • This novel solution demonstrates safety, good clinical tolerance, and does not negatively impact dialysis adequacy.
    • Bicarbonate-based CAPD solutions represent a promising alternative for managing acid-base balance in dialysis patients.