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Related Experiment Videos

Endothelin-1-like immunoreactivity in postobstructive pulmonary vasculopathy

A Giaid1, D J Stewart, R P Michel

  • 1Department of Pathology, Royal Victoria Hospital, Montréal, Canada.

Journal of Vascular Research
|November 1, 1993
PubMed
Summary

Endothelin-1 (ET-1) may contribute to postobstructive pulmonary vasculopathy (POPV) by increasing bronchial neovascularization and pulmonary artery thickening. This study investigated ET-1

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Area of Science:

  • Pulmonary Medicine
  • Cardiovascular Research
  • Vascular Biology

Background:

  • Postobstructive pulmonary vasculopathy (POPV) involves abnormal pulmonary artery changes and bronchial collateral vessel growth.
  • Endothelin-1 (ET-1) is a potent vasoconstrictor peptide implicated in vascular remodeling.

Purpose of the Study:

  • To investigate the role of ET-1 in a canine model of POPV.
  • To assess ET-1 levels and localization in POPV.

Main Methods:

  • Canine model of POPV created by ligating the left main pulmonary artery.
  • Radioimmunoassay to measure plasma ET-1 levels.
  • Immunohistochemistry to localize ET-1 in lung tissues.

Main Results:

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  • Plasma ET-1 levels were similar in ligated and control pulmonary arteries.
  • ET-1-like immunoreactivity was increased in pulmonary arteries and bronchial vessels of ligated lungs.
  • ET-1 staining was specific, confirmed by preabsorption studies.

    • Conclusions:

    • ET-1 may play a role in the neovascularization of bronchial vessels in POPV.
    • ET-1 might contribute to pulmonary arterial thickening observed in POPV.